Director / Senior Director, Pharmaceutical Sciences

Position Details

  • Job Title: Director / Senior Director, Pharmaceutical Sciences
  • Location: New York
  • Job Category: Drug Discovery-Chemistry


We are seeking a highly creative, self-motivated pharmaceutical sciences leader with significant experience in drug discovery to work as a member of an integrated team developing a novel platform for the discovery of new drug targets leading to transformational therapeutics.  The successful applicant will report to the Senior VP – Preclinical Development, contribute to the drug discovery process in target identification through early clinical development, and have the unique opportunity to impact both the strategy and execution of multiple therapeutic programs driven by Kallyope’s cutting-edge biology on the gut and gut-brain axis. 

Candidates for this position will have a passion for identifying and applying effective drug delivery technologies and pharmaceutics methods and a track record of driving results.  Ability to think creatively and solve problems is a must. 


  • Collaborate with drug discovery scientists to advance programs from target validation, lead identification and optimization through candidate nomination and early development including strategy setting and resource prioritization
  • Design enabling preclinical formulations for pharmacology and toxicology studies
  • Optimize preclinical drug candidates’ solid state phase (pharmaceutics, stable polymorph ID, salt selection, etc.)
  • Deliver key data sets for development candidate evaluation
  • Explore external commercial and academic opportunities to apply new technologies related to drug delivery and pharmaceutics
  • Oversee resources at third-party contract research organizations (CROs) and contract manufacturing organizations (CMOs)


You must have:

  • Ph.D, in pharmaceutical science, analytical chemistry or related discipline, or equivalent industrial experience
  • Prior experience (7+ years) in small molecule drug discovery, preclinical development and early clinical formulation development
  • Discovery / early development project team experience
  • Demonstrated scientific productivity and impact, as evidenced by strong publication record and ability to work effectively in a collaborative setting

Additional preferred experience includes:

  • Experience with strategies for gut restricting / gut targeting compounds
  • Experience authoring pharmaceutical sections of CMC documents for regulatory submissions
  • Experience with drug development from preliminary market formulation to approval and commercialization

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