In Vivo Enteric Nervous System/Neuroscience Research Associate

Position Details

  • Job Title: In Vivo Enteric Nervous System/Neuroscience Research Associate
  • Location: New York
  • Job Category: Drug Discovery-Biology

JOB SUMMARY

The In Vivo Enteric Nervous System/Neuroscience Research Associate will be a key member of the team charged with developing, qualifying, and executing in vivo assays in rodents. Specifically, the Research Associate will be part of a team attempting to uncover local gut and gut-brain circuits with the ultimate purpose of translating novel biology to treat disease.  Successful candidates must be able to work effectively both in a collaborative setting and independently while possessing outstanding written, and oral communications skills.

KEY RESPONSIBILITIES

  • Viral transduction of neuronal populations within the brain, gut, and peripheral ganglia that innervate the GI tract.
  • Development and validation of specific assays for more detailed characterization of gut derived biology; i.e. motility, secretion, metabolism, inflammation
  • Single cell and single nucleus sequencing of neuronal populations
  • Assessing CRO capabilities and designing/monitoring/interpreting assays at CROs
  • Execution of in vivo rodent pharmacokinetic/pharmacodynamic (PK/PD) studies including formulation of dosing solutions, dosing, PK/PD sampling and necropsy
  • Compilation of results into comprehensive reports

QUALIFICATIONS AND EDUCATION REQUIREMENTS

You must have:

  • M.S. degree in in a biological science, or B.S. degree with equivalent experience
  • At least two years of hands on research experience
  • Commitment to detail for in vivo study design, execution, and data organization
  • Experience with mouse experimental models

Additional preferred experience includes:

  • Experience with rodent neuroscience and/or gut biology
  • Exposure to rodent surgical procedures (or surgical experience)
  • in vitro assay experience, either cell lines or primary culture
  • Drafting animal protocols and amendments for IACUC review
  • Histology experience (immunofluorescence and in situ hybridization if possible)
  • Working with genetically modified animals, including behavioral phenotyping of rodents after optogenetic and/or chemogenetic manipulation

Apply Now

*required