JOB SUMMARY
The In Vivo Enteric Nervous System/Neuroscience Research Associate will be a key member of the team charged with developing, qualifying, and executing in vivo assays in rodents. Specifically, the Research Associate will be part of a team attempting to uncover local gut and gut-brain circuits with the ultimate purpose of translating novel biology to treat disease. Successful candidates must be able to work effectively both in a collaborative setting and independently while possessing outstanding written, and oral communication skills.
KEY RESPONSIBILITIES
- Viral transduction of neuronal populations within the brain, gut, and peripheral ganglia that innervate the GI tract.
- Development and validation of specific assays for more detailed characterization of gut-derived biology; i.e. motility, secretion, metabolism, inflammation
- Single cell and single nucleus sequencing of neuronal populations
- Assessing CRO capabilities and designing/monitoring/interpreting assays at CROs
- Execution of in vivo rodent pharmacokinetic/pharmacodynamic (PK/PD) studies including formulation of dosing solutions, dosing, PK/PD sampling, and necropsy
- Compilation of results into comprehensive reports
QUALIFICATIONS AND EDUCATION REQUIREMENTS
You must have:
- M.S. degree in a biological science, or B.S. degree with equivalent experience
- At least two years of hands-on research experience
- Commitment to detail for in vivo study design, execution, and data organization
- Experience with mouse experimental models
Additional preferred experience includes:
- Experience with rodent neuroscience and/or gut biology
- Exposure to rodent surgical procedures (or surgical experience)
- in vitro assay experience, either cell lines or primary culture
- Drafting animal protocols and amendments for IACUC review
- Histology experience (immunofluorescence and in situ hybridization if possible)
- Working with genetically modified animals, including behavioral phenotyping of rodents after optogenetic and/or chemogenetic manipulation