Assay Operations Scientist

Position Details

  • Job Title: Assay Operations Scientist
  • Location: New York, NY
  • Job Category: Pharmacology-In Vitro

Job Summary

The assay operations scientist will be a key member of the in-vitro pharmacology group at Kallyope who will guide the assay operations team in developing, qualifying, and executing biochemical and cell-based assays for drug discovery programs. This is a “lead from the bench” role and is expected to be an operational resource for the in-vitro team from cell line development to assay execution.

Key Responsibilities

  • Develop biochemical and cell-based assay according to program needs and company-wide priorities.
  • Optimize, validate, and troubleshoot assay for robustness, sensitivity, reproducibility.
  • Oversee the mammalian cell culture work (development, validation, maintenance, and cell banking).
  • SAR driving assays for lead optimization programs.
  • Communicate effectively to understand the needs of the different program teams in the company.
  • Data management – responsible for data quality and timely distribution.

Qualifications and Education Requirements

You must have:

  • Ph.D. with relevant experience or MS with at least 10 years experience in pharma/biotech.
  • Broad knowledge of pharmacological targets (e.g., receptors, channels, transporters transcription factors and enzymes)
  • Demonstrated understanding of quality parameters in assay development and optimization
  • Diversified technical expertise in mammalian cell culture, biochemical and cell-based assays, etc.
  • Experience working with automated liquid handling systems
  • Commitment to detailed work planning and data organization
  • Ability to balance organization and productivity in face of rapidly changing priorities

Additional preferred experience includes:

  • Automated data handling “from plate reader to dose-response curves” is highly desirable
  • Working knowledge of ion channel assays
  • GPCR pharmacology
  • Biochemical and biophysical assays
  • Experience working with pluripotent stem cells
  • Mentoring and guiding research associates

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